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Kor J Aesthet Cosmetol 2010;8(1): 1-9. |
| 목단피 에탄올 추출물의 B16F10 멜라닌 생선 세포의 저해 작용과 항산화 활성 |
| 허선정, 김경영, 박은영, 장아름, 양기숙, 황완균 |
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| Antioxidation activity and Inhibition of B16F10 melanoma cell from Moutan Cortex from Ethanol Extracts.
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| Sun-jung Hur, Kyoung-youn Kim, Eun-young Park, A-reum Jang, ki-Sook Yang, Wan-kyun Whang |
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| ABSTRACT |
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Moutan Cortex extracts has been reported to have radical scavenging activity. On these facts, biological activity and whitening effect were examined to evaluate a bioactivity of the extracts of Moutan Cortex Radicis by extraction conditions as a possible functional cosmetic agent material. We prepared ethanol extracts. Fractionation is hexane and dichloromethane and ethyl acetate and butanol and water. This is measured DPPH assay, NBT/XO assay, tyrosinase assay and MSH-induced melanin production in B-16 cells and MTT assay. Ethyl acetate and butanol fractionation of Moutan Cortex Radicis showed dose-dependently anti-oxidant activity in DPPH, NBT/XO assay. Also, ethyl acetate fraction significantly inhibited tyrosinase activity and MSH-stimulated melanin production in B-16cells. Therefore, these results suggest that ethyl acetate fraction of Moutan Cortex Radicis will be developed as a functional cosmetic agent, such as excellent whitening agent
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| Key words:
Paeonia sulfruticosa Andrews, Anti-oxidant, Whitening, Tyrosinase, B16F10 melanoma cell
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