Asian J Beauty Cosmetol. 2011; 9: 0.
Effect of MAL Extracts on Cholesterol Metabolism in High Cholesterol Fed Rabbits
ABSTRACT
To investigate the effect of MAL(plant extracts) on cholesterol metabolism, male New Zealand
White rabbits which were fed on high-cholesterol diet for 2 weeks were divided into the following 5
groups and fed on the experimental diet for 8 weeks : a normal diet group(ND, n=6), a high-cholesterol
diet group(HCD, n=6), a high-cholesterol diet and lovastatin0.002%(HCD+lovastatin0.002%, n=6),
a high-cholesterol diet and MAL 1% group(HCD+MAL1%, n=6), a high fat diet and MAL3%
group(HCD+3%, n=6). The levels of blood total cholesterol, LDL-cholesterol and HDL-cholesterol
were greatly increased by 2 weeks feeding on the high-cholesterol diet, compared with those of rabbits
fed on normal diet. Blood concentrations of total cholesterol and LDL-cholesterol increased in
HCD group after 8 weeks, whereas HDL-cholesterol significantly decreased. In the HCD+lovastatin0.002%
group, the levels of blood total cholesterol, triglycerides and LDL-cholesterol were significantly
reduced but there was no significant change in HDL-cholesterol. In the HCD+MAL1%
group, the levels of blood triglyceride was decreased, but not in blood concentrations of total
cholesterol. In the HCD+MAL3% group, the levels of blood total cholesterol and LDL-cholesterol reduced,
in addition to less-severe decrease in HDL-cholesterol. The level of ALT and AST significantly
increased in the HCD+lovastatin0.002% group, but not in groups fed MAL diets. These results
suggest that MAL may improve lipid metabolism of serum and potentially reduce lipid storage.
Keywords :
plant extracts, high-cholesterol diet, total cholesterol, triglyceride
