Asian J Beauty Cosmetol. 2015; 13(1): 49-57.
The Efficacy and Safety Test of New Moisturizing Cream for Dry Skin Condition and Itch Relief
Young-Kyoung Yoo, Min-Sup Lee, Kyoung-Hye Choi, Ghang-Tai Lee, and Kun-Kook Lee
ABSTRACT
This study was conducted to find out the improvement of skin hydration, persistency, transepidermal water loss (TEWL) and itchy of moisturizing cream. The moisturizing cream is containing vernix caseosa mimetic (VCM), Actium lappa seed extract in liquid crystal system. In previous study, We developed vernix caseosa analogues mimicking the unique structure and properties of natural vernix caseosa. Actium lappa seed extract has the effect on lipid synthesis on human keratinocyte. We have investigated whether topical application of moisturizing cream and placebo cream improve the skin hydration, persistency, TEWL and itchy. The number of study participants were 40, including 20 study group (Group B) and 20 control group (Group A). The subjects in study group applied moisturizing cream containing VCM, arctium lappa seed extract in liquid crystal system on face (cheek) and thigh twice a day for 4weeks. The ones in control group applied cream without active ingredients in same methods. The hydration persistency test was conducted with 20 male and female on forearm. Our results showed that moisturizing cream (Group B) improved the skin hydration on cheek and thigh after 2weeks and 4weeks compared with before application. While the control group (Group A) was not showed the skin hydration effect compared with before application. Moisturizing cream (Group B) improve the decreasing TEWL on cheek and thigh after 2weeks and 4weeks compared with before application. But the control group (Group A) improved the decreasing TEWL on cheek after 2weeks and 4weeks compared with before application. Moisturizing cream (Group B) showed high moisturizing value and long holding time of hydration. In this study, we evaluated decreasing itch of moisturizing cream (Group B) and control cream (Group A) by assessment questionnaire. Moisturizing cream (Group B) improve the itch after 2weeks and 4weeks compared with before application. These studies show that moisturizing cream containing VCM and arctium lappa seed extract in liquid crystal system can improve skin hydration, persistency, TEWL and itch in the dry skin.
Keywords : Vernix caseosa mimetic (VCM), Dry skin, TEWL, Moisturization, Itching