Asian J Beauty Cosmetol. 2006; 4(2): 115-128.
Anti-wrinkle effects of Acetyl hexapeptide and Palmitoyl pentapeptide
ABSTRACT
This research was aimed at evaluation of effects of acetyl hexapeptide and palmitoyl pentapeptide
on reducing the appearance of wrinkles or fine lines. To test this, 20 women aged between 32 and
55 years old were selected, and the preceding team were tested from 7 March 2006. Test was completed
within 8 week’s time. Participants were divided into two teams; A team (10 women) consists
of the experimental group who contains 14% acetyl hexapeptide and the control group, B team (10
women) comprises the experimental group who contains 14% palmitoyl pentapeptide, and the control
group. And, to evaluate effects of these compounds on wrinkles on the skin, participants were requested
to use it two times (morning, evening) a day. To examine and judge carefully the efficacy
thereof, evaluations were performed through means of questionnaire and a coputer-based image analyzer,
and the following conclusions were made:
The results from analysis of questionnaires revealed that more participants who belonged to the
experimental group than those who belonged to the control group appraised the effects of use of the
compound on reduction of appearance of wrinkles in their objective manners that it was not significant,
and that there were statistically significant differences. The results from the evaluation of
improvements made on appearance of wrinkles on the skin during the 4th week of the period of
time with weather abnormality caused by yellow sand wind and dry air using Visioscan, the image
analyzer indicated that there were statistically significant differences, and that there were decreases
of appearance of wrinkles on the skin in A team as much as 18% in R1, 21% in R2, and 12% in
R3, and that there were decreases of appearance of wrinkles on the skin in B team as much as 18%
in R1, 23% in R2 and 7.4% in R3. The results from evaluation during the 8th week displayed that
the experimental group in A team experienced effect of reducing appearance of wrinkles at the rate
of 10%, and the experimental group of B team experienced effect of reducing appearance of wrinkles
by 20%. Despite the fact that appearance of wrinkles might have been induced in a more serious
fashion due to problematic skin or excessive appearance of corn and callous at the period of time with environmental changes because of the results of researches in which 14% palmitoyl pentapeptide
will promote to combine collagen, fibroblast and glycosaminoglycans (GAGs) into new whole,
the results from the test showed that there were effects of reduction of the appearance of wrinkles
on the skin, and that there were no statistical significances.
