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Kor J Aesthet Cosmetol > Volume 10(3); 2012 > Article
Kor J Aesthet Cosmetol 2012;10(3): 731-736.
비타민나무 열매로부터 분리한 Quercetin 3-glucoside-7-rhamnoside의 항산화 및 주름개선 효과
이희경
Antioxidant and Anti-wrinkle Effects of Quercetin 3-Glucoside-7-Rhamnoside Isolated from Hippophae rhamnoides Fruits
Hee-Kyung Lee
ABSTRACT
Although many studies have been performed to search materials that regulate skin aging, little is known about the effect of quercetin 3-O-glucoside-7-O-rhamnoside (Q3G7R) from Hippophae rhamnoides (H. rhamnoides ) L. fruits. In this study, we identified Q3G7R from H. rhamnoides L. fruits, and then measured the antioxidant activity of Q3G7R by 1,1-diphenyl-2-picryl hydrazyl (DPPH) method and its cytotoxicity in human dermal fibroblasts using sulforhodamine B (SRB) assay. Also, we investigated effect of Q3G7R on procollagen synthesis and TNF-α induced Matrix Metalloproteinase-1 (MMP-1) expression in human dermal fibroblasts. As the results, Q3G7R didn’t exhibit cytotoxicity at 100 μg/mL showing cell viability over 100 % and antioxidant activity with 56.4% at concentration of 1 mg/mL. Procollagen synthesis in human dermal fibrolasts increased about 2 times higher than control by treatment with 1 μg/mL of Q3G7R. TNF-α induced MMP-1 expression was reduced to 85.58 ng/mL by treatment with 1 μg/mL of Q3G7R. Therefore, these results suggest that Q3G7R can be effective antioxidant and antiwrinkle ingredient for cosmetics applications.
Key words: Q3G7R, Hippophae rhamnoides , Antioxidant, Procollagen, Anti-wrinkle
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