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Kor J Aesthet Cosmetol 2012;10(1): 91-97. |
| 흑삼의 아토피 억제활성에 대한 연구 |
| 신영진, 장현희, 송규용 |
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| Study on Anti-atopic Effects of Black Ginseng |
| Young Jin Shin, Hyun Hee Jang, Gyu Yong Song |
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| ABSTRACT |
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The purpose of this study is to investigate the influence of black ginseng (BG) on induced IL-6, IL-8 and MCP-
1 secretion by house dust mite in THP-1 (human acute monocytic leukemia cell line) and EoL-1 (human
eosinophilic leukemic cells) cell lines. The house dust mite (Dermatophagoides pteronissinus, D. pteronissinus )
plays a key role in the pathogenesis of allergic diseases, including atopic dermatitis and asthma. Monocyte
chemoattractant protein 1 (MCP-1), interleukin-6 (IL-6) and interleukin-8 (IL-8) play a pivotal role in mediating
the infiltration of various cells into the skin of atopic dermatitis. The korean ginseng (radix and leaf) was steamed
to 3 hr at 120℃ under high pressure. The contents of benzopyrene which was known as a tumor promoting
agent were analysed. Also, the inhibitory effect of BG on the induced IL-6, IL-8 and MCP-1 secretion by D.
pteronissinus extract (DpE) in THP-1 and MCP-1 cells was examined. The BG extract (radix and leaf) potently
suppressed the elevated production of IL-6 and IL-8 induced by DpE treatment in THP-1 and EoL-1 cells.
Among them, the crude saponin fraction of BG leaf exhibited the most potent inhibitory activity. Based on the
present results, it can be suggested that the 3 hr steaming at 120℃ under high pressure is the most optimal
processing condition and BG may be useful to develop functional food on atopic dermatitis. |
| Key words:
Black ginseng, Anti-atopic effect, IL-6, IL-8, MCP-1 |
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