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Kor J Aesthet Cosmetol 2012;10(4): 941-948. |
| Phytosphingosine-1-phosphate가 함유된 나노리포좀 제조 및 피부 노화 개선 효과 |
| 이정표, 이광식, 이건국, 안성관, 이동규 |
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| Preparation of Phytosphingosine-1-phosphate Nano-liposome and Its In Vivo Anti-aging Improvement Effects of Finished Products |
| Jeong Pyo Lee, Kwang Sik Lee, Kun Kook Lee, Sungkwan An, Dong Kyu Lee |
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| ABSTRACT |
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Cosmetic scientists always effort to find new effective anti-aging raw materials. In the previous study, we reported
that Phytosphingosine-1-phosphate (PhS1P) could have function as an anti-aging material in cosmetic through
its role in the regulation of stress-induced growth arrest in dermal fibroblasts. In this study, in order to know the
application for cosmetic raw materials, the nano-liposome contained PhS1P was prepared using microfluidizer
(3 times, 1,000 bar), and tested in in-vivo human test using a finished product. The PhS1P nano-liposome
was confirmed by a particle size analyser (the mean size is 158.4nm), SEM, HPLC, Percutaneous Absorption.
It has shown that PhS1P nano-liposme was prepared successfully. In order to know the effectiveness of the
nano-liposome on skin, we tested in in-vivo human test. The elasticity, thickness, and dermal density of applied
skin was checked by using cutometer and Dermascan-C. The test results shown that the elasticity of skin was
improved 15.87% after 2 weeks, 27.34% after 4 weeks, 31.57% after 8 weeks compared to unapplied skin.
The thickness of applied skin was improved 9.51% after 2 weeks, 13.95% after 4 weeks, 17.67% after 8 weeks
compared to unapplied skin. The dermal density of applied skin was improved 3.14% after 2 weeks, 3.77% after
4 weeks, 5.03% after 8 weeks compared to unapplied skin. There was no significant skin irritation on human
volunteer test. These results show that PhS1P nano-liposome has a good anti-aging effect on human skin.
Therefore, we suggest that PhS1P will be a good cosmetic raw material for anti-aging products. |
| Key words:
Phytosphingosine-1-phosphate, Nano-liposome, Anti-aging, Cosmetics, Raw material |
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