| C57BL/6 마우스에서 꽃송이버섯 추출물의 에틸아세테이트층과 물층의 분리에 따른 발모 효과 |
| 류은미, 신현재 |
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| Hair growth effect of ethyl acetate and water fractions of Sparassis crispa extracts on hair-removed C57BL/6 mice |
| Eun-Mi Ryu, Hyun-Jae Shin |
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| ABSTRACT |
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Sparassis crispa is an edible and medicinal mushroom, which commonly called ‘cauliflower mushroom’.
S. crispa is known to be good sources of food and nutraceuticals due to their rich flavors
and β-glucan contents as well as antiviral and anticancer compounds. C57BL/6 mice, the widely
used lab mouse strain, were used in this animal study because of their availability and a similar
hair growth cycle to human hair. Herein, hair-removed five-year-old C57BL/6 mice were used to
examine the effect of S. crispa extracts for 70% ethanol extract, ethyl acetate extract, and water
extract on hair growth stimulation. The extracts and control compounds were topically treated once
a day for 4 weeks. The hair growth was photographically and histologically examined during the total
period of 4 weeks. Overall, hair growth of S. crispa water extracts test group was stimulated
compared to ethyl acetate extract and 70% extract, along with positive control (3% minoxidil) and
negative control (normal). The whole study showed a significant improvement of hair growth effect
of S. crispa extracts. This findings suggests that S. crispa extract has a hair growth promoting activity,
but more works should be planned to elucidate the hair growth mechanism. |
| Key words:
Sparassis crispa extracts, Alopecia, scalp, Hair growth, C57BL/6 mouse |
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