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Kor J Aesthet Cosmetol 2013;11(5): 877-882. |
| 홍삼에 함유된 프로토파낙사트리올계 전환사포닌의 피부주름 개선효과 |
| 이상명, 임영호, 김석창, 최재환, 김진희 |
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| Anti-wrinkle Effects of Converted Protopanaxatriol Prepared from Korean Red Ginseng
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| Sang Myung Lee, Young Ho Im, Seok Chang Kim, Jae Hwan Choi, Jin Hee Kim |
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| ABSTRACT |
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In order to study about human skin anti-wrinkle effect of red ginseng, red ginseng extracts and the fractions were tested to inhibition effect against MMP-2, -9, and -1 expression in human fibroblast cells by gelatin zymography and RT-PCR methods. The red ginseng samples are red ginseng extract extracted with hot water, crude saponin as butanol soluble fraction, major ginsenosides, protopanaxatrol conversions, protopanaxadiol conversions as the fractions fractionated by C18 revers phase resin and various proportions of aqueous acetonitrile. We found that propanaxatriol conversions fraction one of the red ginseng samples inhibited in a concentration-dependent manner against MMP-2, and -9 expression levels in human fibroblast cells irradiated by UV light. By HPLC analysis, protopanaxtriol conversions fraction consisted on ginsenosides Rk3, F4, Rg6, and Rh4. These results suggest that dehydrates of protopanaxatriol ginsenoside from red ginseng have an antiwrinkle activity through inhibition of MMP-2, and -9 expression in skin.
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| Key words:
Panax ginseng, Protopanaxatriol, MMPs, Anti-wrinkle
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