| 인공피부를 이용한 피부자극 대체시험법 소개 |
| 김배환 |
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| The introduction of alternative method of reconstructed human skin equivalents for the assessment of skin irritation |
| Bae-Hwan Kim |
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| ABSTRACT |
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Because many materials for skin application can induce the skin irritation, we should evaluate the
primary skin irritation test. Recently, several alternative in vitro methods to Draize skin irritation
test using rabbits have been developed. The most promising alternative method for skin irritation is
the using of reconstituted human skin equivalent model(RhE). In this study, we introduce the development
status of RhE model, principle and procedure of test method, and validation method. Further
studies are in progress to improve the test protocols and the validation studies for KeraSkinTM developed
by Korea in order to be certified internationally. |
| Key words:
Skin irritation, Alternative method, RhE, KeraSkin |
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