| 화장품 원료개발을 위한 파리유충과 土龍추출물의 생리활성기능 조절에 관한 연구 |
| 장문정, 안명수 |
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| Stuies on the Bioactivity Modulation of Maggot and Earthworm
Extracts for the Development of Cosmetic Resources |
| Moon-Jung Chang, Myung-Soo Ahn |
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| ABSTRACT |
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The present study was undertaken to develop the available resources for cosmetics including
health foods or medicine from natural resources. The biofunctional activities such as anti-microbial
activity, antioxidation activity, and immune modulation activity were investigated by using several
extracts from earthworm, maggot and seaweeds. In results, anti-microbial or anti-bacterial activities
of extracts from maggots and earth worms, both hot water and solvent extracts showed high anti-
microbial activities against Streptococcus, g(+), Salmonella, choleraesuis subup. g(-),
Pseudomaonas aeruginosa g(-), Escherichia coli. g(-), Bacillus subtilis g(+).
Meanwhile, the earthworm including intestine contents was extracted with ethanol, anti-microbial
activity was not observed against Pseudomonas aeruginosa g(-). In case of Escherichia coli. g(-),
anti-microbial activity was only observed in the earthworm extracts excluding intestinal contents.
Furthermore, the anti-microbial activity of earthworm extracts against fungus such as
Staphylococcus warneri, Staphylococcus xylosus and Staphylococcus hominis subup. Hominis, was
only found in the extracts including intestinal contents. In case of extracts of earthworm excluding
intestinal contents, both hot water and ethanol extracts showed strong anti-microbial activity
against Staphylococcus warneri, but no anti-microbial activity was observed against Staphylococcus
xylosus. Anti-microbial activity against Staphylococcus hominis subup. hominis was found only in
the group treated with the extracts of earthworm excluding intestinal by ethanol. The maggot extracts
showed the clear increase of proliferation activity at the level of 100ppm, but the higher concentration
of maggot extract showed the lower proliferative activities, and cytotoxic effect was observed
in splenocytes treated with over 5000ppm of maggot extract. Meanwhile, when splenocytes
were treated with 100ppm and 500ppm of earthworm extracts, the proliferation activity was increased
in dose dependent manner.
In the results of antioxidation activities of maggot and earthworm extracts, DPPH production was
not inhibited by earthworm extracts but maggot extracts showed significant inhibitory effects of
DPPH production as much as 50% of Vitamin C when treated with 10000ppm. It has been thought
that the comparatively lower effects of earthworm extracts on DPPH inhibition may be due to the
lower concentration of responsible compound in the extracts. Likely the case of DPPH inhibition,
the earthworm extracts did not show any inhibitory effects on TBARS. In summary, the extracts
of maggot, seaweeds and earthworm showed increased anti-microbial activities, anti-oxidative function
and immune modulation activities. All together, it has been suggested that the extracts from
natural product such as maggot and earthworm can be developed and used for functional substances
in the fields of cosmetics. |
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