Asian J Beauty Cosmetol. 2015; 13(6): 935-940.

Effects of α-Mangostin on Gene Expression of Keratin1, Involucrin, and Loricrin in HaCaT Keratinocytes and Improvement of Nail Gloss

Jung-Min Ko, Song Hee Han, and Kyu Joong Ahn

Skin is the largest organ of the human body, which surrounds and protects body from external environments. Skin is divided in epidermis and dermis layer, and especially, epidermis is composed three layers each known as spinous, granular and cornified layer. Though various cell types constitute epidermis such as melanocytes, keratinocytes and langerhans cells, over 95% of epidermis consists of keratinocytes. As differentiation arise, the major component of epidermis, keratinocytes gradually proceed differentiated state from cell cycle. The differentiation of keratinocytes is the most important functional role in formation of stratum corneum, thus protects body from microbial invasion and inhibits hydration of skin. Due to diverse function of skin biology, keratinocytes has been studied mainly in pathology about toxicology, chemicals, and cosmetology. Alpha-mangostin (α-mangostin) is a yellow colored agent, which is the first xanthone isolated from Garcinia mangostana (mangosteen). According to previous study, α-mangostin has biological effects such as anti-inflammation and antioxidant properties. The aim of this study was to investigate how α-mangostin promotes calcium induced differentiation of human epidermal keratinocytes, HaCaTs, and improves gloss of the nail.

Keywords : α-Mangostin, Keratinocyte, Differentiation, Nail, Gloss